Genetic and familial aspects of narcolepsy. Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep. Mieda M, Hasegawa E, Kisanuki YY, Sinton CM, Yanagisawa M, Sakurai T. Differential expression of orexin receptors 1 and 2 in the rat brain. Marcus JN, Aschkenasi CJ, Lee CE, Chemelli RM, Saper CB, Yanagisawa M, Elmquist JK. Hypothalamic hypocretin (orexin): robust innervation of the spinal cord. Reduced number of hypocretin neurons in human narcolepsy. Thannickal TC, Moore RY, Nienhuis R, Ramanathan L, Gulyani S, Aldrich M, Cornford M, Siegel JM. The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. ![]() Neurons containing hypocretin (orexin) project to multiple neuronal systems. Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS. Distribution of orexin neurons in the adult rat brain. Nambu T, Sakurai T, Mizukami K, Hosoya Y, Yanagisawa M, Goto K. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. 2003 92(3):259–66.ĭate Y, Ueta Y, Yamashita H, Yamaguchi H, Matsukura S, Kangawa K, Sakurai T, Yanagisawa M, Nakazato M. Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. Zhu Y, Miwa Y, Yamanaka A, Yada T, Shibahara M, Abe Y, Sakurai T, Goto K. Acute suppressive and long-term phase modulation actions of orexin on the mammalian circadian clock. doi: 10.3389/fendo.2013.00057.īelle MD, Hughes AT, Bechtold DA, Cunningham P, Pierucci M, Burdakov D, Piggins HD. Differential roles of orexin receptors in the regulation of sleep/wakefulness. ![]() The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. 1998 92(4):573–85.ĭe Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett 2nd FS, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M. Here, we review the current understanding of how the orexinergic system regulates sleep and wakefulness and how its deficiency causes narcolepsy. Thus, the discovery of a causal relationship between deficient orexin signaling and narcolepsy has allowed tremendous progress in our understanding of the pathophysiology of narcolepsy, as well as raised the possibility of novel diagnoses and treatments for narcolepsy. Furthermore, the replacement of orexins may prevent narcoleptic symptoms in animal models of narcolepsy. Orexin neurons are thought to maintain and stabilize wakefulness through their interaction with monoaminergic and cholinergic neurons implicated in the regulation of states of sleep and wakefulness, and they are mediated by two G-protein-coupled receptors that show differential expression patterns depending on brain region and neuron type. Selective degeneration of orexin-producing neurons has been established as the cause of human narcolepsy, a debilitating neurological disease characterized by excessive daytime sleepiness and cataplexy. Orexins (hypocretins) are neuropeptides expressed exclusively by neurons in the lateral and perifornical hypothalamus in the brain.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |